Source: The Unbearable Weight of Massive Talent
Nicolas Cage is looking at Pedro Pascal with a serious, intense expression while driving. Pedro Pascal looks over at him, breaking into a massive, joyful, and slightly unhinged-looking smile. The camera cuts back and forth between their expressions as they cruise in a car.
This video is widely used to represent a contrast between two types of people, a buildup to a punchline, or a reaction to someone being intense while you are just happy to be there. It's often called the 'Pedro Pascal smiling at Nicolas Cage' meme.
